The move came as the summer holiday started in Spain and the country began re-admitting foreign visitors from 12 countries outside the European union.
It had already opened its frontiers to people from the EU's visa-free Schengen zone and Britain on June 21.
"We have decided to confine the del Segria zone following data confirming a sharp rise in COVID-19 infections," Catalonia's regional president Quim Torra told reporters, adding that no one would be allowed to enter or leave the area.
Regional health minister Alba Verges said gatherings of more than 10 people and visits to retirement homes would be banned.
Spain has been one of the countries worst hit by the coronavirus pandemic with 28,385 deaths, Europe's fourth-highest toll after the United Kingdom, Italy and France.
On Friday, it registered 17 virus deaths within 24 hours, its highest daily COVID-19 toll since June 19.
The number of cases now stands at 250,545 in a country of 47 million.
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