Firefighters were continuing to battle blazes in Bolbaite and Carcaixent, towns south of Valencia city inland from the coast.
Authorities chose to evacuate the Hospital de Aguas Vivas in Carcaixent during the night on Thursday, transferring some three dozen patients to nearby hospitals in the Valencia region.
Residents in two urbanizations were also advised to leave their homes as flames raged across hillsides nearby and were put up overnight in the sports centre.
A reported 74 neighbours were told to leave houses in the Sumacárcer development and another 100 from Las Marinas.
There were reports of several houses being consumed by flames but no reported injuries beyond one person being treated for smoke inhalation.
On Friday morning, a new blaze started in the hills above Les Valles near Sagunt.
The head of emergency services in the region estimated that some 2,000 hectares of forest had been destroyed.
“We have more than 20 teams working to combat the fires from the air and around 100 firefighters on the ground,” José María Ángel, told SER radio station.
One local councillor tweeted footage of flames threatening to engulf the hospital in Carcaixent.
Huge smoke plumes were visible along the coast.
The wildfires were visible from space with the Meteosat satellite picking up images of the blaze as it orbited 36,000 km from Earth.
A 19-year-old man was arrested on Friday suspected of starting a fire in Bolbaite.