Sylwia Rajchel, a 23-year-old Erasmus student at Spain's Murcia University, tumbled over a low stone wall and fell seven metres onto the concrete bank of the river Guadalquivir in the early hours of Sunday morning, according to local daily El Correo de Andalucía.
Emergency services were called and found her in a state of cardio-respiratory arrest. They performed CPR on the scene and transferred the woman to the nearby Virgen del Rocio Trauma Hospital where her condition was described as "extremely critical".
Doctors were unable to save her, however. She died of her injuries on Monday, according to Spain's El Mundo newspaper.
It is believed that it was the student's first-ever visit to the Andalusian city.
Authorities said the area in question did not have fencing or other security measures as the site was heritage listed. "We did everything we could," said Seville mayor Juan Ignacio Zoido after the accident.