The snake made its escape from a home in the Catalonian town of Riells i Viabrea eight days ago and is still on the loose.
Local police and volunteers have now launched a snake hunt for the albino Burmese python which weights in at a hefty 10kg, according to Spain's Antenna 3 television station.
Police have also opened judicial proceedings against the animal's owner for negligence.
The serpent's owner allegedly housed the snake in substandard conditions and failed to notice the animal had made a run for it.
The snake is not poisonous but does have a habit of strangling small prey to death, especially at night.
"Locals have no reason to fear because the animal isn't dangerous and because it would have been difficult for the animal to leave the zone (around the house where it left)," local police assured residents.
Anyone who spots a two-metre-long python with burnt orange and yellow spots is advised to contact the authorities.
Burmese pythons are one of the five largest snakes in the world and can reach lengths of up to 5.7 metres.