The figure represented a decline of 6.17 percent from 2017, a ministry statement said, without providing a standard unemployment rate.
But even though unemployment has dropped since 2013 as Spain emerges from an economic crisis, the country still has the eurozone's second highest jobless rate after Greece.
Data from the EU statistics agency Eurostat put the 19-member zone's average unemployment rate at 8.1 percent in October.
The latest Spanish jobless rate, meanwhile, was 14.55 percent.
The ministry's annual number of unemployed was nonetheless the lowest since 2009.
Economy minister Nadia Calvino told Spanish radio that “the Spanish economy is creating jobs at a good rhythm.”
She forecast the economy will have grown by 2.6 percent in 2018, slightly stronger than a 2.5 percent forecast by the central bank and International Monetary Fund.
In calculating the number of unemployed, the labour ministry only takes into account those people who have signed up to a job agency.
As such, their figure is lower than that of Spain's INE statistics agency.
At the end of October, INE said there were 3.33 million umemployed people in Spain — a jobless rate of 14.55 percent that was slightly below Eurostat's figure.
Spain's Socialist government plans to inject two billion euros ($2.3 billion) into fighting youth unemployment, which it wants to reduce to 23.5 percent within three years.
Unemployment peaked in 2013 when it reached over 26 percent (see graph below):