With these two greats of the modern age having moved on, AFP Sport picks out six new signings to watch in the coming campaign.
THOMAS LEMAR (ATLETICO MADRID)
Position: Attacking midfielder/winger
Previous club: Monaco (FRA)
It is Atletico Madrid who have made the biggest signing of the summer in Spain, spending €72 million ($84 million) on Lemar.
The left-footed 22-year-old, who hails from the Caribbean island of Guadeloupe, is the latest member of Monaco's brilliant 2017 French title-winning side to move on.
He comes fresh from winning the World Cup with France, although his involvement on the field in Russia was limited. Lemar's association with national team colleague Antoine Griezmann will be particularly interesting to watch.
MALCOM ( FC BARCELONA)
Previous club: Bordeaux (FRA)
Iniesta has gone to Japan and the biggest signing coming into the Camp Nou is the young Brazilian winger Malcom. The 21-year-old was a surprise arrival from French side Bordeaux, with Barca agreeing to pay 41 million euros to sign him on a five-year deal from right under the noses of Roma.
The champions moved for Malcom after giving up their pursuit of Chelsea winger Willian. Adept at coming in from the right wing onto his left foot, Malcom scored 12 goals in Ligue 1 last season.
The player who began his career at Corinthians offers coach Ernesto Valverde a valuable extra option in attack.
ARTURO VIDAL (FC BARCELONA)
Previous club: Bayern Munich (GER)
Barcelona's summer has also been notable for their failure to complete the signing of Griezmann, and for Paulinho's return to China.
The decision to bring in Chilean midfielder Vidal gives Valverde another experienced option in midfield as the Catalans seek to retain the title and end Madrid's hegemony in the Champions League.
Vidal, 31, has won league titles in each of the last seven seasons over spells with Juventus and Bayern, and he also played in the Juve team that lost to Barcelona in the 2015 Champions League final.
THIBAUT COURTOIS (REAL MADRID)
Previous club: Chelsea (ENG)
Rather than a marquee name to replace Ronaldo, Real's biggest signing is a new goalkeeper. Belgian number one Courtois returns to Spain from Chelsea on a six-year deal for a reported 35 million euros.
Keylor Navas is still at the Bernabeu, but Courtois should usurp him as first-choice goalkeeper after being granted his wish to come back to Spain, where his children live with his ex-partner.
Courtois joined Chelsea in 2011 but was immediately loaned out to Atletico Madrid and spent three years there, winning La Liga with Diego Simeone's side in 2014. However, he has hailed his move to Real “a dream come true”.
WILLIAM CARVALHO (BETIS)
? OFICIAL | El #RealBetis se refuerza con el internacional portugués William Carvalho ✍
¡Bienvenido, @wllmcarvalho14! ??
— Real Betis Balompié (@RealBetis) July 13, 2018
Previous club: Sporting (POR)
For years, tall Portuguese international midfielder Carvalho had been linked with a big money move abroad from Sporting.
Finally this summer the transfer happened, with Carvalho joining the exodus of players to leave the Lisbon side after they were the victims of a violent attack by a gang of masked fans at their training ground.
But rather than move to England, the Angolan-born Carvalho has joined Europa League hopefuls Betis. The Seville side will hope his arrival helps them establish themselves towards the top of the table.
MICHY BATSHUAYI (VALENCIA)
— AS English (@English_AS) August 12, 2018
On loan from: Chelsea (ENG)
Valencia are gearing up for a return to the Champions League and have moved to strengthen in attack, with French striker Kevin Gameiro joining from Atletico for a reported 16 million euros. Batshuayi's arrival is particularly interesting though.
The Belgian international joins on a one-year loan from Chelsea, where he has struggled to establish himself since signing from Marseille two years ago. But he did well on loan at Borussia Dortmund in the second half of last season, and if he can carry that form on throughout this campaign, Valencia could be a fearsome proposition going forward.