Padilla's appearance in the December 2nd show in London will be the fourth by a Spanish model in an event which helps sell millions of dollars worth of lingerie for US firm Victoria's Secret.
It will also see the 19-year-old lined up with top models including Adriana Lima and Alessandra Ambrosio who will both wear the label's so-called Fantasy Bras valued at $2 million for the fashion show.
"I have no words to describe how happy and excited I am, I feel so honored to be part of such an incredible project. Thank you supporters and everyone who believed in me!!" said Padilla, announcing the news on her Instagram site.
Padilla's appearance at the Victoria's Secret show is the latest chapter in a staggering year for the young model. Less than a year ago, she was discovered by modelling talent scout Ignacio Aysa while she was changing trains at Madrid's Plaza de España metro station.
She then went on to win the L’Oréal prize for the best model at Madrid Fashion Week in February. She has also participated in fashion weeks in New York, Milan and Paris for designers including Dolce & Gabbana, Spanish daily La Vanguardia reported.