The 29-year-old Facebook chief announced the stock and cash purchase on Wednesday, a deal that marries his social network of 1.2 billion active users with Whatsapp's 450 million users.
Asked about the price tag during an on-stage discussion at the February 24th-27th Mobile World Congress in Barcelona, Spain, Zuckerberg said WhatsApp was attractive as a company by itself, and as a strategic fit with Facebook.
"I just think that by itself it is worth more than $19 billion," said Zuckerberg, wearing a grey t-shirt, sneakers and black trousers.
"I mean it is hard to exactly make that speech today because they have so little revenue compared to that number," he conceded.
"But the reality is that there are very few services that reach a billion people in the world. They are all incredibly valuable, much more valuable than that," he added.
"I could be wrong. This could be the one service that gets to a billion people and ends up not being that valuable. I don't think I am."
Other Android messaging applications such as KakaoTalk, Vine and WeChat were already bringing in two to three dollars a person "with pretty early efforts", he said.
"That shows that if we can do a pretty good job of helping WhatsApp to grow then this is just going to be a huge business," Zuckerberg said.
"So even just independently I think it is quite a good bet."
In partnership with Facebook, WhatsApp can focus on connecting "one, two, three billion people over the next however long that is going to take," Zuckerberg said.
The Facebook boss said he and WhatsApp founder Jan Koum shared a vision of connecting everyone in the world to the Internet, delivering development benefits and in the longer term profits, too.
Zuckerberg said Facebook planned to leave the WhatsApp service unchanged.
"WhatsApp doesn't store the content," he said. "We would be pretty silly to get in the way of that."
Hours earlier, WhatsApp's Koum said the messaging service would launch free voice calls by mid-year, putting it on a par with key competitor Viber which already does so.
He, too, stressed that Facebook did not plan to change WhatsApp. "Mark really understands that for WhatsApp to be successful it really needs to stay independent," he said.
Zuckerberg has come a long way in the mobile world in a short time.
When Facebook sold its shares to the public in an initial public offering in May 2012, "it literally had no mobile advertising revenues", said Eden Zoller, analyst at the research house Ovum.
"It did actually have a pretty strong mobile user base at IPO but what it had failed to do at that time was actually monetise those mobile users," she said.
At the time of the float, worries over the lack of money coming in from the mobile business sent Facebook's shares sliding.
But the social network — boasting more than 1.2 billion members — quickly repaired its strategy.
By the end of 2013, mobile devices accounted for 53 percent of Facebook's advertising revenue, bringing in $1.2 billion in the last quarter and more than $3 billion over the whole year.