The weekly service, operated by LD Lines, will link the southern Irish port town of Wexford with St Nazaire on the west coast of France and Gijón in northern Spain.
"It's the first service of its kind to Ireland," Ireland's Tourism Minister Leo Varadkar told The Irish Times.
"It's great news for our tourism industry and it provides a valuable new land bridge from France and Spain into Ireland".
Online booking will be available soon.
Rosslare (Wexford) – Gijón service fares start from €579 for a car and two passengers including cabin.