The report, which looked at the student dropout rate in all member states, found that Spain was the worst in the class with 24.9% of pupils quitting school prematurely in 2012.
Malta and Portugal were the next worst offenders with a 22.6 percent and 20.8 percent leave school without completing their studies.
In Spain the school leaving age is set at 16, with students having the choice to stay on until 18 to study for the "Bachillerato".
Eurostat's research, which was published on Thursday, highlighted that boys were 24 percent more likely than girls to cut short their studies in all member states.
Another recent study by Spanish recruiting agency Asemepleo found that nearly 33 percent fewer young people are now actively seeking work than when the crisis hit in the third quarter of 2007 and other figures, published in Spanish media on Monday show more and more students are also going abroad to study.
Spain’s crippling crisis has seen the number of Spanish youths (aged between 15 and 29) who do not hold a job or a place on a study or training course increase.