Bigas Luna, as he was simply known, directed more than a dozen films over his 35-year career.
Perhaps his best-known for international audiences was "Jamón Jamón" (1992), a raunchy comedy which starred newcomer Cruz and up-and-coming fellow Spanish actor Javier Bardem.
Both Cruz and Bardem went on separately to Hollywood careers and later became a real-life couple, marrying in 2010.
A decade before "Jamon Jamon", Bigas Luna had tried his own hand in Hollywood, making "Reborn" with Dennis Hopper in the lead, but the movie garnered little notice.
Bigas Luna kept working in Spain up to his death. In recent months he was preparing to film in his native city of Barcelona a movie called "Second Origin", a science fiction tale about Earth after an apocalyptic alien attack.